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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL3
All Species:
15.45
Human Site:
Y378
Identified Species:
26.15
UniProt:
Q8IVW4
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IVW4
NP_001107047.1
592
67514
Y378
S
E
P
K
K
K
E
Y
E
G
G
L
G
Q
Q
Chimpanzee
Pan troglodytes
XP_517934
592
67566
Y378
S
E
P
K
K
K
E
Y
E
G
G
L
G
Q
Q
Rhesus Macaque
Macaca mulatta
XP_001108660
592
67612
Y378
S
E
P
K
K
K
E
Y
E
G
G
L
C
Q
Q
Dog
Lupus familis
XP_850612
456
51739
Q268
D
I
V
D
A
C
L
Q
I
D
P
A
E
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8BLF2
595
67720
Y380
P
D
Q
K
K
P
E
Y
E
G
D
H
R
Q
Q
Rat
Rattus norvegicus
Q9JM01
593
67534
S380
P
D
L
K
K
T
E
S
E
G
E
H
R
Q
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512927
637
71445
H377
S
E
A
Q
K
N
D
H
G
S
V
H
C
H
G
Chicken
Gallus gallus
P13863
303
34670
G115
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
Frog
Xenopus laevis
P35567
302
34487
Q114
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
V162
C
D
Y
Y
T
D
C
V
A
T
R
W
Y
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
L109
S
E
L
V
R
S
Y
L
Y
Q
I
T
S
A
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784044
926
104004
E349
L
E
R
E
R
E
K
E
K
S
R
K
R
H
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
S106
K
N
P
T
L
I
K
S
Y
L
Y
Q
I
L
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
T106
K
D
L
H
M
I
K
T
Y
L
Y
Q
I
L
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
67.7
N.A.
80.5
79
N.A.
57.7
25
24.3
31
N.A.
23.4
N.A.
N.A.
30.2
Protein Similarity:
100
99.8
99.6
72.1
N.A.
89.7
87.6
N.A.
68.9
34.9
35.6
43
N.A.
35.1
N.A.
N.A.
44
P-Site Identity:
100
100
93.3
0
N.A.
53.3
46.6
N.A.
20
0
6.6
0
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
6.6
N.A.
60
53.3
N.A.
40
20
13.3
13.3
N.A.
20
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
22.8
N.A.
23.1
N.A.
N.A.
Protein Similarity:
N.A.
33.9
N.A.
33.9
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
0
0
0
8
0
0
8
0
8
8
% A
% Cys:
8
0
0
0
0
8
8
0
0
0
0
8
22
0
0
% C
% Asp:
8
29
0
8
0
8
8
0
0
8
8
0
0
0
0
% D
% Glu:
0
43
0
8
0
8
36
8
36
0
8
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
15
36
22
0
15
0
8
% G
% His:
0
0
0
8
0
0
0
8
0
0
0
22
8
22
8
% H
% Ile:
0
8
0
0
8
22
0
0
15
8
8
0
15
0
8
% I
% Lys:
15
0
0
36
43
22
22
0
8
0
0
8
0
0
0
% K
% Leu:
8
8
29
0
8
8
15
8
0
15
0
22
0
15
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
15
0
29
0
0
8
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
8
15
8
0
8
15
0
8
0
15
0
36
36
% Q
% Arg:
0
0
8
0
15
0
0
0
0
0
15
0
22
15
15
% R
% Ser:
43
0
0
0
0
8
0
15
0
15
0
0
8
8
15
% S
% Thr:
0
0
0
8
8
8
0
8
0
8
0
8
0
0
8
% T
% Val:
0
0
8
8
0
0
0
8
0
8
15
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
8
8
15
15
0
0
8
29
22
0
15
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _